Transcatheter aortic valve replacements alter circulating serum factors to mediate myofibroblast deactivation

Transcatheter Aortic Valve Replacement: A Review Article

Transcatheter aortic valve replacement (TAVR) is a novel therapeutic intervention for the replacement of severely stenotic aortic valves in high-risk patients for standard surgical procedures. Since the initial PARTNER trial results, use of TAVR has been on the rise each year. New delivery methods and different valves have been developed and modified in order to promote the minimally invasive p...

Transcatheter aortic valve implantation for stenosed and regurgitant aortic valve bioprostheses CoreValve for failed bioprosthetic aortic valve replacements.

Transcatheter aortic valve implantation is increasingly being used to treat severe aortic stenosis in patients with high operative risk. In an aging population the incidence of aortic stenosis is rising, and increasing numbers of elderly patients are undergoing aortic valve replacement with bioprosthetic valves. Therefore, there is a corresponding increase in prosthetic degeneration. This prese...

Transcatheter aortic valve implantation in degenerate failing aortic homograft root replacements.

Transcatheter Aortic Valve Replacement

With the worldwide number of TAVR procedures rapidly approaching 200,000, coupled with an amassed knowledge spanning over a decade, we are able to now reflect on the evolution of TAVR and how changes in technology, operator/institution experience, and patient selection have ultimately affected clinical outcomes. With this in mind, in this issue of JACC: Cardiovascular Interventions, Beohar et a...

Transcatheter Aortic Valve Implantation

A 97-year-old man was referred for assessment to our transcather aortic valve implantation (TAVI) team. He had suffered multiple hospitalizations for heart failure with a signifi cantly elevated BNP at 1830 pg/mL. At the time of assessment, he had grade IV New York Heart Association (NYHA) symptoms. Until recently, he had been working actively, but this had subsequently been severely limited by...